Review : Cross - Validation and the Free - RDr

نویسنده

  • Kevin Cowtan
چکیده

Macromolecular crystallography is an example of a scientiic measurement problem which starts with a diiraction pattern and ends with an atomic model. The path in between is suuciently complex that it is hard to relate the precision of the nal model to the original measurements. As a result it is hard to distinguish between an improvement to the model which ts a genuine feature of the signal, and one which merely ts noise in the data. A statistical technique, Cross Validation, is available to counter this problem. Its crystallographic application has been pioneered by Axel Br unger in the form of the Free-R factor (Br unger, 1992).

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تاریخ انتشار 2007